“New York, January 22 (ANI): According to a study done by the Mayo Clinic Comprehensive Cancer Center, women with breast cancer in one breast may be more likely to get breast cancer in the other breast if they have certain genetic changes that make them more likely to get cancer.
The study’s results, which were published in the Journal of Clinical Oncology, will, the study’s authors say, make it easier to tailor cancer screening and risk factors to each person.
As part of the Cancer Risk Estimates Related to Susceptibility (CARRIERS) consortium, information was collected from 15,104 women who were watched over time. These facts were used to figure out the results. Researchers found that people who had a germline mutation in BRCA1, BRCA2, or CHEK2 were at least twice as likely to get cancer in the other breast .
On the other hand, patients with germline ATM mutations were not more likely to get breast cancer on the other side of the body. On the other side, it was much more likely to happen to PALB2 carriers who had a disease that didn’t have an oestrogen receptor.
Fergus Couch, PhD, Zbigniew Scheller, and Anna M. Scheller, both professors of medical research at the Mayo Clinic Comprehensive Cancer Center, along with his team, did the CARRIERS Study. Couch really knows a lot about breast cancer. “These are the first numbers for these three genes other than BRCA1/2 that are based on a population,” says Couch. It is one of the biggest studies to try to figure out how likely it is that a woman with a genetic change from her mother will get cancer on the other side of her body.
Siddhartha Yadav, MD, a medical oncologist at the Mayo Clinic’s Comprehensive Cancer Center and co-author of the paper, says that people with breast cancer who have germline mutations often think they have a higher chance of getting cancer in the other breast. This isn’t the case. Even though this is known to be true for people with the BRCA1/2 mutation who get breast cancer, the risk of getting cancer on the other side was not known until now for people with a mutation in ATM, CHEK2, or PALB2. No one had ever tried to figure out how likely it was for people with the BRCA1/2 mutation to get breast cancer on the other side of their bodies, taking into account things like age, oestrogen receptor status, menopause status, and how the primary tumour was treated.
Dr. Yadav says that their findings are important because “they reveal important information that will help in a personalised assessment of contralateral cancer risk in our patients who are germline mutation carriers.” With this much information, patients and their care teams can make better decisions about screening and reducing the risk of cancer on the other side.
Researchers found that women with germline mutations who haven’t gone through menopause are more likely to get cancer on the other side of their body than women who have already gone through menopause. The study found that both black and non-Hispanic white women with germline mutations in genes that make people more likely to get cancer had a higher risk of getting it on the other side. This means that the ways both groups handle risks should be the same.
Symptoms of Breast Cancer
- An enlargement of the breast, the chest, or the underarm
- Alterations in the skin’s texture, such as dimpling and puckering
- Observation of a change in the colour of the breast, which may become crimson or inflamed.
- A little modification, such as when it’s drawn in slightly more than before (inverted)
- A rash that looks like a nipple and has a crusty top layer can appear anywhere on the skin.
- A discharge of a liquid that cannot be identified coming from both nipples
- Changes in the size and shape of the breasts
- Breast pain refers to discomfort felt in either one or both of the breasts.